Extracolonic cancers in Lynch syndrome

MSI cancers are not limited to the colorectum. There are many MSI cancers in other organs, most commonly affecting the endometrium. We hypothesize that depending on the organ of origin, the evolutionary conditions during tumor development may vary significantly. This would have wide-ranging impact on the mutational landscape and the neoantigen spectra of extra-colonic MSI cancers. Whereas the coding microsatellite and neoantigen patterns of MSI colorectal cancers is well studied, data on molecular and immonological features of extracolonic MSI tumors are scarce.

In this project we aim at deciphering mutational landscapes and neoantigen patterns of extracolonic cancers. This knowledge will help us to precisely design vaccines based on the characteristic of certain tumor types and may pave the way towards a pan-MSI cancer vaccine.