Alexej Ballhausen

As a medical student, I started working on my thesis in the Department of Applied Tumor Biology in early 2016. My main research interest is to decipher the role of coding microsatellite (cMS) mutations and resulting frameshift neoantigens in MSI-H cancer development and anti-tumoral immune responses.

We have developed an algorithm to quantitatively score these mutations and model their individual immunogenicity. Using this novel tool we could unravel the frameshift neoantigen landscape of MSI CRCs and many more exciting details about the distribution of cMS mutations in subsets of MSI-H cancers.

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