Dr. Malwina Michalak
As a proud member of the ATB team since 2013, I am currently working as a postdoctoral researcher. After finishing my training in biotechnology I have started to work under the supervision of Prof. J. Kopitz as a Marie Cure Early Stage Researcher, broadening and applying my proteomics expertise in glycobiology of colorectal cancer. Following my PhD project I am investigating the structure, expression and role of carbohydrate – binding proteins, called galectins, in colorectal cancer. My recent interests has been also focused on studying the effects of targeting carbohydrate metabolism on cell surface proteome and its glycosylation in colorectal cancer cells that could be further applied in novel therapeutic approaches based on recognition of altered glycoprotein structures.
Publications / Output
Kopitz J, Xiao Q, Ludwig AK, Romero A, Michalak M, Sherman SE, Zhou X, Dazen C, Vértesy S, Kaltner H, Klein ML, Gabius HJ, Percec V. Reaction of a Programmable Glycan Presentation of Glycodendrimersomes and Cells with Engineered Human Lectins To Show the Sugar Functionality of the Cell Surface. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14677-14681. PMID: 28940633
Ludwig AK, Michalak M, Shilova N, André S, Kaltner H, Bovin NV, Kopitz J, Gabius HJ. Studying the Structural Significance of Galectin Design by Playing a Modular Puzzle: Homodimer Generation from Human Tandem-Repeat-Type (Heterodimeric) Galectin-8 by Domain Shuffling. Molecules. 2017 Sep 19;22(9). PMID: 28925965
Fricke F, Lee J, Michalak M, Warnken U, Hausser I, Suarez-Carmona M, Halama N, Schnölzer M, Kopitz J, Gebert J. TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. Cell Commun Signal. 2017 Apr 4;15(1):14. PMID: 28376875
Michalak M, Warnken U, André S, Schnölzer M, Gabius HJ, Kopitz J. Detection of Proteome Changes in Human Colon Cancer Induced by Cell Surface Binding of Growth-Inhibitory Human Galectin-4 Using Quantitative SILAC-Based Proteomics. J Proteome Res. 2016 Dec 2;15(12):4412-4422. PMID: 27801591