Johannes Witt

Studying medicine in Heidelberg, I am particularly interested in getting a better understanding of tumor cell evolution, potentially leading to novel therapeutic targets and prevention strategies. Lynch syndrome associated cancers are highly immunogenic, therefore representing an ideal starting point for investigating interactions between emerging tumor cell clones and the immune system. During the work for my doctoral thesis, I analyzed the association between MSI patients’ HLA type and the mutation pattern of coding microsatellites bearing target genes. In this context, the INDICATE project may contribute to uncovering the role of HLA molecules during the process of immunoediting and cancer development.

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