Fabia Fricke, PhD student

Throughout my education, I became highly fascinated by the strategies of tumor cell communication based on the shed of extracellular vesicles (EV). In 2012, I have first joined the Dept. of Applied Tumor Biology. Working in ATB drives a spirit that emphasizes both teamwork and investigations at the interface between high-class research and innovative clinical applications. After my graduation in Translational Medical Research at Heidelberg University, I received a 3-year scholarship of the Helmholtz International Graduate School for Cancer Research.

My PhD project under the supervision of Prof. Dr. Jürgen Kopitz and Dr. Johannes Gebert is focussed on the biology and function of extracellular vesicles (“exosomes”) and the diagnostic potential in colorectal cancers that lack DNA mismatch repair function and present microsatellite instability. It became my long-term mission to broaden the scientific understanding about the molecular concepts of exosome-mediated communication in colorectal cancers to optimize clinical strategies.

Current research topics

Publications / Output

Fricke F, Lee J, Michalak M, Warnken U, Hausser I, Suarez-Carmona M, Halama N, Schnölzer M, Kopitz J, Gebert J. TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. Cell Commun Signal. 2017 Apr 4;15(1):14. PMID: 28376875

Lee J, Fricke F, Warnken U, Schnölzer M, Kopitz J, Gebert J. Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells. PLoS One. 2015 Jun 26;10(6):e0131506. PMID: 26114631

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