Eva-Maria Katzenmaier
I joined the ATB 2013 for my PhD as a passionate biologist interested in tumor biology and biochemistry under the supervision of Prof. Dr. Kopitz and Dr. Gebert. During my PhD I mainly focused on deciphering the contribution of glycan-binding proteins, called Galectins, on colon cancer tumorigenesis in an in vitro model system. After my graduation in 2017 I have continued working in this field as a postdoctoral researcher.
Apart from studying molecular alterations during colon carcinogenesis in humans I currently investigate molecular alterations in a mouse model for microsatellite unstable cancers. This project aims to identify potential tumors drivers that could be used for vaccination strategies in a clinical setting in the future. Both projects share the enthusiasm for basic tumor biology which represents the fundament for translating basic research into clinical application.
Publications / Output
Katzenmaier EM, Stark HJ, Gebert J, Kopitz J. Galectin-12 colocalizes with splicing factor-rich speckles and shuttles between the nucleus and cytoplasm in colon cancer cells. Journal of Molecular Biochemistry (2018) 7, (28-40)
Katzenmaier EM, Kloor M, Gabius HJ, Gebert J, Kopitz J. Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer. IUBMB Life. 2017 Dec;69(12):962-970. PMID: 29098769
Lee J, Katzenmaier EM, Kopitz J, Gebert J. Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1. Cell Signal. 2016 Aug;28(8):1105-13. doi: 10.1016/j.cellsig.2016.04.012. Epub 2016 May 5. PMID: 27156840
Katzenmaier EM, André S, Kopitz J, Gabius HJ. Impact of sodium butyrate on the network of adhesion/growth-regulatory galectins in human colon cancer in vitro. Anticancer Res. 2014 Oct;34(10):5429-38. PMID: 25275038