I joined the Department of Applied Tumor Biology at Heidelberg University Hospital in April 2024 as a postdoctoral researcher, following my PhD in Cancer Genomics at Sorbonne University (Paris, France). During my doctoral research, I investigated the molecular mechanisms underlying microsatellite instability (MSI)-driven colorectal carcinogenesis, from early precancerous lesions to established tumours. My work particularly focused on coding and non-coding microsatellite alterations, revealing the contribution of MSI-associated alternative splicing to early tumour development, cellular dedifferentiation and immune recognition.

My current research focuses on understanding the earliest stages of hereditary carcinogenesis, using Lynch syndrome as a model. Through the DECIPHER project, I integrate histopathology, molecular profiling, spatial analysis and bioinformatics to investigate the emergence and evolution of mismatch repair (MMR)-deficient lesions across different tissues. A particular focus is the characterization of MMR-deficient crypt foci, their spatial distribution and the biological mechanisms governing their persistence, expansion and potential progression towards malignancy.

By combining multi-omics approaches with tissue-level observations, my research aims to better understand the transition from normal epithelium to cancer and identify opportunities for earlier intervention and personalized cancer prevention. This work also contributes to collaborative initiatives, including the NCI-funded CAP-IT consortium, dedicated to advancing cancer immunoprevention.

I was awarded a postdoctoral fellowship by the Alexander von Humboldt Foundation to support my research in Heidelberg. In recognition of my research on early mutational and immunogenic events in Lynch syndrome carcinogenesis, I received the Axel Kahn Award in Oncogenomics (SFMPP, 2025).